Reflections from ECCMID 2015

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This year’s ECCMID meeting in Copenhagen was universally accepted to be the first one with a significant infection prevention and control component, although it would be fair so say that the sessions were not the best attended, meaning that levels of interest in infection control in the majority of the infectious disease physicians attending still need to be stimulated. There were a number of significant sessions, one of which entitled ‘The year in infection control’ was a whistle-stop tour through the most significant papers of 2014 as selected by Petra Gastmeier, Eli Perencevich and Stephanie Dancer. This was a rollercoaster of a session and the abstracts presented are available here. There was, as you would imagine an interest in Chlorhexidine bathing with a very interesting debate between Stephan Harbarth (in favour) and Andreas Voss (against). The main argument against seemed to be that compliance is poor and so why bother. This in fact was a major theme at the meeting, where many papers were presented, in some of which interventions had little effect however the implementation just did not take place.

There were a couple of interesting abstracts. Michelle Allen presented the pilot to her very interesting cleaning bundle study that has some positive initial results (poster here).

The second was a small study from Turkey, unfortunately not an e-poster, that used a Chlorhexidine wipe to cleanse the genital area prior to sending a urine specimen showed impressive results in reducing contaminants and the need for repeat specimens and possibly warrants further investigation in a well-designed study since most micro labs are submerged under the number of inclonclusive urine specimens that result in repeats being requested and possible treatment delays.

The third was from Prof Hilary Humphreys group in Dublin, which looked at the use of chlorine on mattress covers contaminated with Carbapenem resistant Klebsiella pneumoniae, demonstrating that they survive for longer on mattress fabric and are more resistant to hypochlorite than other carbapenem-resistant Enterobacteriaceae. The link to the abstract is here

Will there be as much attention on IPC at ECCMID 2016 in Instanbul? Watch this space

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Contamination of the air: cause or effect?

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There’s an ever increasing wealth of data that contamination of hospital surfaces are important in the transmission of key hospital pathogens. However, the importance of contaminated air in the transmission of these pathogens is much less certain.

There are some pathogens – like measles – for which airborne spread is by far the most important route. But for the most common pathogens associated with healthcare-associated infection, including MRSA, VRE, C. difficile, A. baumannii and norovirus, contaminated air has not been considered to be an important reservoir, historically.

A recent study published in Clinical Infectious Diseases provides some data that contaminated air may be more common than previously thought. The authors collected 48 air samples from 8 hospitals during outbreaks. Samples were collected close to patients, outside their rooms and at nurses’ stations. The authors found norovirus nucleic acid in 6/8 hospitals from which samples were taken, and at a concentration of 101 to 103 per m3. Finally, they also did some lab work demonstrating that an aerosol of a norovirus surrogate (murine norovirus) preserved its infectivity.

A few key technical questions arise: how do you know whether the norovirus was viable? The authors did not actually attempt to grow the norovirus and could have detected nucleic acid from dead virus particles. If the norovirus is alive, is there enough of it there to cause an infection? (The minimum infective dose of norovirus can be as low as one virus particle, so the answer, in theory, is yes.) A follow-on question from this is: if there is so much viable norovirus floating around in the air, why doesn’t everybody get it?

A more fundamental question is whether the contaminated air detected in this study is a cause or effect of norovirus transmission. For many years, contaminated surfaces were considered to be an effect rather than a cause of transmission and it took detailed intervention studies to convince the scientific community that contaminated surfaces can be a cause of transmission. In the case of norovirus – and other pathogens associated with healthcare-associated infection – we don’t yet have those convincing intervention studies that contaminated air is a cause of transmission.

However, the theoretical risk is there and I’m sure that those of us who have experienced norovirus would prefer to err on the side of caution rather than acquire norovirus via an airborne route!

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Welcome to our blog

We thought it was about time to start a blog. The idea is that this becomes a forum for education and discussion. We will be posting blogs about the latest developments in the literature surrounding infection prevention and control. Our interests are around environmental, patient and hand hygiene, education of patients and staff, how we can best deploy new technology, and the economics of healthcare-associated infection. So, you can expect the content to reflect these interests.

We are keen for this to be a conversation and not a lecture, so please submit any comments that you may have and let’s get some discussion going!

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