C. difficile lurking in the laundry


A US study has found C. difficile spores in the hospital laundry. Whilst most of the spores were identified on the dirty side of the laundry, a small number of spores were also identified on the clean side of the laundry. The identification of C. difficile spores in both the clean and dirty hospital laundry could present a potential transmission risk.

The study team sampled 120 surfaces in the dirty side of the laundry, and 120 surfaces on the clean side of the laundry. C. difficile was identified from around 1 in 5 surfaces on the dirty side, and 1 in 50 surfaces on the clean side. Whilst is not surprising to find contamination with C. difficile spores on the dirty side of the laundry, it is a concern to find these spores on the clean side, where hospital linen is folded before being taken to clinical areas. Furthermore, there is a risk of laundry workers becoming contaminated with the spores and sharing them with other parts of the hospital.

The findings of this study prompted a review of the workflows of staff between the dirty and clean areas of the laundry, resulting in increased disinfection of surfaces, and changes in how staff moved between the dirty and clean sides of the laundry. Perhaps this study should also prompt a review of cleaning and disinfection protocols, and staff workflows in your hospital laundry?


BETR-D study demonstrates the clinical impact of UV-C

The long-awaited BETR-D study has finally been published, in the Lancet. The huge cluster randomised controlled trial proves that UV-C is effective in reducing the rate of acquisition of VRE and MRSA, and argues strongly for the adoption of UV-C to improve patient safety.
This is a very impressive study. It’s a huge two year cluster-randomised controlled trial (RCT) spanning nine US hospitals, which is the absolute gold standard for a study of an infection control intervention. The hospitals implemented a randomised sequence for four different terminal disinfection approaches: QAC, QAC+UV, bleach, bleach+UV. There was a statistically significant 31% reduction in the acquisition of target organisms (MRSA, VRE and C. difficile) for patients admitted into rooms disinfected using QAC+UV compared with QAC alone. The effect on VRE was bigger than on MRSA. When C. difficile patients were removed from the analysis, there was a statistically significant 28% reduction in the acquisition of target organisms (MRSA and VRE) for patients admitted into rooms disinfected using bleach + UV compared with bleach alone. It is worth noting that the QAC + UV arm was not inferior to the bleach + UV arm, suggesting that bleach cleaning prior to UV isn’t necessary. Environmental sampling showed trends that matched the clinical reductions (UV pretty much eliminated MRSA and VRE, but didn’t reduce the level of C. difficile contamination. The study was exceptionally well controlled, with rates of hand hygiene, compliance with standard cleaning, and colonisation pressure all meticulously measured and shown not to change. UV disinfection added only 10 minutes to room turnaround time.

There was no clinical impact on C. difficile in this study, in contrast to a number of other studies, which have showed that UV-C reduces the acquisition of C. difficile. Could it be that the levels of reduction in spores that UV-C systems are able to achieve are not high enough to reduce significantly the acquisition rate of C. difficile? Or perhaps there was something about the way that UV-C was applied in this study that explains this apparent discrepancy? In this study, the UV-C system was staged at a single point in the patient room, and a separate cycle was not performed in the bathroom (which isn’t our recommended use of the Clinell UV-360!). It would be interesting to see whether altered device staging and multiple cycles improve the clinical impact of UV-C against C. difficile.
Overall though, this is a powerful study, which argues strongly for the adoption of UV-C into a hospital’s disinfection strategy for the terminal disinfection of rooms vacated by patients with MRSA / VRE, and perhaps C. difficile as well.


Choosing between different UV automated room decontamination systems

There is increasing evidence that UV-based automated room decontamination systems reduce the transmission of key hospital pathogens. There seems to be an exponential multiplication of suppliers of UV room decontamination systems! So how to choose between the many options available? An article in AJIC provides a framework for making this decision. The evidence shows that UV-C systems are more effective than pulsed-xenon systems. Beyond that, the decision between UV-C systems will depend on a number of factors. Here, we review the various parameters that are discussed in the article, explaining why we chose the Clinell UV-360 room sanitiser.

  • UV-C or pulsed-xenon? The evidence is clear that UV-C systems are more effective than pulsed-xenon UV systems, when run for the same amount of time from the same point in the room under controlled laboratory experiments.

  • Data collection. It is vital that a UV system has a mechanism to collect and export data on the usage of the system in a user friendly format, in order to ensure that the actual usage of UV is as anticipated, and focussing on areas with the highest risk.

  • Measured or timed dose? Whilst a measured dose is appealing in theory, it adds cost and complexity to the UV-C system, and what value does it add? The evidence shows that a timed dose is just as effective as a measured dose of UV!

  • To paint or not to paint? There is some evidence that using UV reflective paint may help to increase the efficacy of UV systems. Implementing UV reflective paint can be costly and has logistical challenges, but it seems that if you plan to us UV regularly, it will be worth it.

  • Cost and cost-effectiveness. It is important to keep the costs of a UV room decontamination system low to give the best chance of achieving cost-effectiveness.
  • The evidence base is clear that conventional methods of cleaning are not always adequate to reduce the risk of transmission to an acceptable level, arguing strongly for the use of automated room decontamination systems, such as UV-C, to augment conventional cleaning and disinfection. GAMA have carefully reviewed the UV market and chosen the UV-360 room sanitiser as their UV-C system of choice! If you would like further information, please get in touch!


    Protecting the patient by effective surface cleaning and disinfection

    GAMA have just released a new version of the Protecting the Patient book providing a summary of the latest evidence that contaminated surfaces contribute to transmission, and an overview of the various approaches that can be taken to improve surface cleaning and disinfection, and in doing so protecting patients. Please contact us if you’d like a copy.


    The book begins with a summary of evidence that HCAIs can develop as a result of an inadequately disinfected healthcare environment. Routes of transmission are complicated, involving contaminated hands, surfaces, medical, equipment, air, patients, pets, visitors etc, so it can be difficult disentangle which route is most important. Also, the most important route of transmission is likely to vary considerably by organism and setting. Some pathogens are “more environmental” than others (the spore-forming C. difficile and hardy norovirus being prime examples). But contaminated surfaces can be involved, directly or indirectly, in the transmission of pathogens not considered to be an environmental problem historically (such as MRSA and antibiotic resistant Gram-negative bacteria). Key guidelines (such as epic3) now include clear recommendations around the importance of a clean and appropriately disinfected healthcare environment.

    Despite this evidence, and the best efforts of those involved in hospital cleaning and disinfection, surfaces in hospitals remain persistently contaminated with key pathogens, and this is a risk to patients. The book goes on to provide an overview of the various ways that hospital cleaning and disinfection can be improved, covering:

    ·         Education and training

    ·         Objective measures of hygiene (such as fluorescent markers)

    ·         Choosing the right product (including the growing evidence base for pre-impregnated disinfectant wipes)

    ·         Perspectives on appropriate laboratory testing of hospital disinfectants

    ·         New technology that can help (such as microfiber, antimicrobial surfaces, and automated room decontamination technology including ultraviolet light and hydrogen peroxide vapour)

    screenshot-2017-01-06-19-10-00    screenshot-2017-01-06-19-09-48     
    Click the thumbnails to enlarge

    Please contact us if you’d like a copy.




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