An interesting research brief from Germany has appeared in Infection Control and Hospital Epidemiology this week (view it here). Reusable surface disinfection wipe containers, so much in vogue in the UK a few years ago, have been found to be contaminated with Achromobacter spp.
Achromobacter were collected routinely in clinical isolates in four centres under study and on one occasion, an isolate from cerebrospinal fluid from a brain shunt, following being typed by pulsed-field gel electrophoresis, was found to be an identical strain as found in the reprocessed container. Despite there being protocols for reprocessing the containers, 47% of samples from the reusable containers were contaminated with bacteria. The authors noted that there was no suspicion that the containers were becoming contaminated during the initial manufacturing process, indicating that the
environment was the most likely source of contamination. The quaternary ammonium compound solutions that were used to dose the containers during reprocessing were checked and found to be satisfactory. The authors suggest that the presence of an identical Achromobacter spp. strain in multiple reusable dispenser disinfectant solutions and a clinical specimen from the same institution indicates a potential safety hazard, especially considering the high levels of contamination (in some cases 1Ã—104 colony forming unity per ml).
Perhaps the conclusion is a little surprising then, especially given that this does not seem to be a 'one-off' issue*. The authors state "reprocessing of these dispensers according to the manufacturer's recommendations seems to be crucial to prevent contamination of dispensers with the potential of transmission of pathogens and possible consecutive infections of patients". Perhaps moving to a flow-wrap system where reprocessing is not required, reducing reprocessing and transportation costs as well as the risk of contamination would be a more pragmatic solution.
* Kampf G, Degenhardt S, Lackner S, Jesse K, von Baum H, Ostermeyer C. Poorly processed reusable surface disinfection tissue dispensers may be a source of infection. BMC Infect Dis 2014;14:37.
* Kampf G, Degenhardt S, Lackner S, Ostermeyer C. Effective reprocessing of reusable dispensers for surface disinfection tissues - the devil is in the details. GMS Hyg Infect Control 2014;9: Doc09.
A study from Australia (click here for article) has found biofilms pretty much everywhere on an Australian ICU. The research team cut out 44 surfaces from the ICU and identified biofilms on 41 (93%) of them. This finding will be surprising for some, since biofilms are traditionally associated with hard surface - liquid interfaces (teeth, ship hulls, implanted medical devices). But this is not the first report of biofilms on dry hospital surfaces (click here for article), so isn't out of the blue.
The existence of biofilms on dry surfaces is perplexing. How do they develop in the first place? And how do they survive in the absence of an obvious nutrient or water source (aside from ambient humidity)? Perhaps the very action of cleaning provides some measure of nutrients - put another way, is our daily cleaning only serving to feed the biofilms?
Now that we know biofilms are there on dry surfaces, we need to make some changes to how we approach hospital cleaning and disinfection. Biofilms will not be removed by a cursory wipe with a detergent. We need to develop new agents and new approaches to tackle biofilms. GAMA is on the forefront of this new frontier having recently commenced a KTP partnership with Cardiff University (click here for article) to investigate new approaches to biofilm management. Watch this space for some solutions to the challenge of biofilms on dry hospital surfaces as they emerge!
A study from New York reports a reduction in C. difficile infection associated with the introduction of a pulsed-xenon UV (PX-UV) device. The authors performed a before-after study of the impact of adding PX-UV to the terminal disinfection protocol of rooms housing patients requiring contact precautions, with 12 months before and 12 months after implementation. Overall, there was a non-significant 22% reduction in the rate of CDI (from 1.06 to 0.83 cases per 1000 patient days), and a significant 70% reduction in the ICU (from 1.83 to 0.55 cases per 1000 patient days).
The authors note a change in cleaning contractor towards the end of the pre-intervention period, which could be a confounding factor. And a change in paediatric case mix, which may explain the marginal increase in CDI rates in paediatrics. More importantly, there is a comment in the discussion intimating that PCR testing may have been implemented during the study period, which would be a much more important confounder - but it is not clear whether PCR testing was implemented in the study hospitals or surrounding hospitals.
The authors introduce an unfortunate new term into the literature: "UVD" (ultraviolet light for room decontamination). This is used by the authors as a "catch-all" term to encompass both ultraviolet-C (UVC) and pulsed-xenon UV (PX-UV) devices. This is unfortunate because a recent study shows that a UVC device was, photon for photon, more effective than a PX-UV device.
In the discussion, the authors comment that "Mercury bulbs emit a continuous low pressure light at a single range of 254 nm, and the effect of this UV light is cumulative requiring a longer cycle time of approximately 45 minutes for spore reduction." Whilst the recommended cycle times for UVC devices are indeed longer than for PX-UV to address contamination with spores, the head-to-head study showed that UVC is more effective than PX-UV when run for the same length of time from the same point in the room. Put another way, a short blast of UVC would do more damage to spores than the same short blast of PX-UV. In the case of this study, if a UVC device had been run as per the PX-UV device, you'd expect to see more of an impact on the spores - and possibly more of an impact on CDI transmission.
The authors also comment that "Pulsed xenon devices also are somewhat safer because mercury-based devices can release toxic gases if they break accidentally." This issue has been stirred up by manufacturers of PX-UV devices. The amount of mercury in the bulbs is tiny, and there are fail-safe systems in place to ensure that no mercury is released in the event of breakage. The truth is that a fluorescent bulb that you would see in an office block is more hazardous than the bulbs in UVC devices!
So, it seems that in line with other studies, augmenting terminal disinfection with a UV device does reduce C. difficile transmission. But there does not seem to be a good reason to choose PX-UV over a UVC device!
An oral abstract presented1 (click here for the full report) at APIC 2015 in Nashville in the last week has added to the burgeoning pile of evidence supporting the use of 2% Chlorhexidine wipes in reducing healthcare-associated infections. The paper reported that there was a 59% reduction in Paediatric Central Line-Associated Bloodstream Infection (CLABSI) during the study period. What is interesting about this study is that compliance with the intervention over the course of the study was reported, something that is rarely done. Compliance increased from 45% to 81% during the six-month study period. Significantly, the intervention was demonstrated to be effective even though by the end of the study one in five patients did not receive it. This brings into question our understanding of compliance with research protocols, so poorly reported when study results are published. The researchers estimated potential cost savings of $297,999 over the six-month implementation period. Are staff made aware of the financial aspect of what they are doing in addition to a human one?
If the intervention was significantly effective even when not universally applied, what would the results have been if there had been 100% compliance. How many studies do not reach significance and are deemed to be ineffective because of a low level of compliance with the planned intervention? It would also be interesting to know what the reasons were for the level of compliance with the intervention. Was this poor staff engagement, a lack of understanding of the rationales for the study, practical issues like product unavailability or staff shortage so that the replacements were unaware of the study or patient-specific issues?
It would be very interesting to see a lack of 'success' in a planned intervention examined in this way so that lessons can be learnt and shared to optimise the outputs of research. It is difficult enough to plan and implement a research study. To see it fail because of a lack of compliance with the research protocol is something that should be avoided at all costs.